{"id":1067,"date":"2021-02-09T09:27:47","date_gmt":"2021-02-09T09:27:47","guid":{"rendered":"http:\/\/localhost\/replace\/casa\/"},"modified":"2025-08-12T12:54:56","modified_gmt":"2025-08-12T12:54:56","slug":"casa","status":"publish","type":"page","link":"https:\/\/www.replace-study.com\/es\/","title":{"rendered":"Inicio"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1067\" class=\"elementor elementor-1067\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5a10c8e7 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5a10c8e7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6416d444\" data-id=\"6416d444\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-48045ffb elementor-widget__width-inherit elementor-widget elementor-widget-shortcode\" data-id=\"48045ffb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n\t\t\t\t<p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t\t<sr7-module data-alias=\"home-slider-ES\" data-id=\"15\" id=\"SR7_15_1\" class=\"rs-ov-hidden\" data-version=\"6.7.52\">\n\t\t\t\t\t<sr7-adjuster><\/sr7-adjuster>\n\t\t\t\t\t<sr7-content>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_15_1-7\" data-key=\"7\">\n\t\t\t\t\t\t\t<sr7-bg id=\"SR7_15_1-7-10\" class=\"sr7-layer\"><noscript><img decoding=\"async\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/globeheader.png\" alt=\"Globe Header\" title=\"Globe Header\"><\/noscript><\/sr7-bg>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_15_1-7-2\" class=\"sr7-layer\">Estudio <strong>REPLACE <\/strong><\/sr7-txt>\n\t\t\t\t\t\t\t<p id=\"SR7_15_1-7-3\" class=\"sr7-layer\"><\/p>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_15_1-7-9\" class=\"sr7-layer\">Estudio prospectivo, internacional, randomizado, multic\u00e9ntrico, de dos ramas, controlado, a 24 semanas, abierto, de fase IV <\/sr7-txt>\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_15_1-14\" data-key=\"14\">\n\t\t\t\t\t\t\t<sr7-bg id=\"SR7_15_1-14-16\" class=\"sr7-layer\"><noscript><img decoding=\"async\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/globeheader.png\" alt=\"Globe Header\" title=\"Globe Header\"><\/noscript><\/sr7-bg>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_15_1-14-2\" class=\"sr7-layer\">El estudio <strong>REPLACE<\/strong><\/sr7-txt>\n\t\t\t\t\t\t\t<p id=\"SR7_15_1-14-3\" class=\"sr7-layer\"><\/p>\n\t\t\t\t\t\t\t<a id=\"SR7_15_1-14-7\" class=\"sr7-layer\" href=\"https:\/\/www.thelancet.com\/journals\/lanres\/article\/PIIS2213-2600(20)30532-4\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">Haga click aqu\u00ed para ver la publicaci\u00f3n <i class=\"fa-chevron-right\"><\/i><\/a>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_15_1-14-9\" class=\"sr7-layer\">est\u00e1 ahora publicado en<\/sr7-txt>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_15_1-14-15\" class=\"sr7-layer\">The Lancet Respiratory Medicine.<\/sr7-txt>\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_15_1-20\" data-key=\"20\">\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t<\/sr7-content>\n\t\t\t\t\t<image_lists style=\"display:none\">\n\t\t\t\t\t\t<img data-src=\"\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/rightangle.png\" data-libid=\"96\" data-lib=\"medialibrary\" alt=\"Right Angle\" title=\"Right Angle\" width=\"0\" height=\"0\" data-dbsrc=\"Ly93d3cucmVwbGFjZS1zdHVkeS5jb20vd3AtY29udGVudC91cGxvYWRzLzIwMjAvMDgvcmlnaHRhbmdsZS5wbmc=\"\/>\n\t\t\t\t\t\t<img data-src=\"\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/globeheader.png\" data-libid=\"97\" data-lib=\"medialibrary\" alt=\"Globe Header\" title=\"Globe Header\" width=\"0\" height=\"0\" data-dbsrc=\"Ly93d3cucmVwbGFjZS1zdHVkeS5jb20vd3AtY29udGVudC91cGxvYWRzLzIwMjAvMDgvZ2xvYmVoZWFkZXIucG5n\"\/>\n\t\t\t\t\t\t<img data-src=\"\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/REPLACE-ms-screenshot.jpg\" data-libid=\"1288\" data-lib=\"medialibrary\" title=\"REPLACE ms screenshot\" width=\"0\" height=\"0\" data-dbsrc=\"Ly93d3cucmVwbGFjZS1zdHVkeS5jb20vd3AtY29udGVudC91cGxvYWRzLzIwMjEvMDMvUkVQTEFDRS1tcy1zY3JlZW5zaG90LmpwZw==\"\/>\n\t\t\t\t\t<\/image_lists>\n\t\t\t\t<\/sr7-module>\n\t\t\t\t<script>\n\t\t\t\t\twindow.SR7 ??={};SR7.PMH ??={}; SR7.PMH[\"SR7_15_1\"] = {cn:100,state:false,fn: function() { if (window._tpt!==undefined && window._tpt.prepareModuleHeight !== undefined) {  _tpt.prepareModuleHeight({id:\"SR7_15_1\",el:[400,400,400,300,180],type:'standard',shdw:'0',gh:[400,400,400,300,180],gw:[1240,1240,1024,778,480],vpt:['-200px&#039;,&#039;-200px&#039;,&#039;-200px&#039;,&#039;-200px&#039;,&#039;-200px'],size:{fullWidth:true, fullHeight:false},mh:'0',onh:0,onw:0,bg:{color:'{\"orig\":\"transparent\",\"type\":\"solid\",\"string\":\"transparent\"}'},plType:'0',plColor:'#FFFFFF'});   SR7.PMH[\"SR7_15_1\"].state=true;} else if(SR7.PMH[\"SR7_15_1\"].cn-->0)\tsetTimeout( SR7.PMH[\"SR7_15_1\"].fn,19);}};SR7.PMH[\"SR7_15_1\" ].fn();\n\t\t\t\t<\/script>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b294145 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5b294145\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-76704f39\" data-id=\"76704f39\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5a258297 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5a258297\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3921c4b4\" data-id=\"3921c4b4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a886c6 animated-fast elementor-widget elementor-widget-image\" data-id=\"7a886c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"674\" height=\"424\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/REPLACE-Arrows.jpg\" class=\"attachment-2048x2048 size-2048x2048 wp-image-974\" alt=\"\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/REPLACE-Arrows.jpg 674w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/REPLACE-Arrows-300x189.jpg 300w\" sizes=\"(max-width: 674px) 100vw, 674px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-123b4921\" data-id=\"123b4921\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-17276d94 elementor-widget elementor-widget-heading\" data-id=\"17276d94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bienvenido al estudio REPLACE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-623fa237 elementor-widget elementor-widget-text-editor\" data-id=\"623fa237\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Los datos cl\u00ednicos indican que entre el 20%-60% de los pacientes con <span id=\"su_tooltip_69d0b1dc9f4ec_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dc9f4ec\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">HAP<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dc9f4ec\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">HAP, hipertensi\u00f3n arterial pulmonar<\/span><\/span><span id=\"su_tooltip_69d0b1dc9f4ec_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> que se encuentran recibiendo <span id=\"su_tooltip_69d0b1dc9f611_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dc9f611\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dc9f611\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69d0b1dc9f611_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> no logran alcanzar o mantener los objetivos de tratamiento. El cambio a riociguat puede ser una opci\u00f3n de tratamiento para estos pacientes. El estudio REPLACE evalu\u00f3 la eficacia y seguridad del cambio de <span id=\"su_tooltip_69d0b1dc9f6cc_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dc9f6cc\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dc9f6cc\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69d0b1dc9f6cc_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> a riociguat comparado con permanecer con <span id=\"su_tooltip_69d0b1dc9f785_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dc9f785\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dc9f785\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69d0b1dc9f785_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> en pacientes con <span id=\"su_tooltip_69d0b1dc9f82b_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dc9f82b\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">HAP<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dc9f82b\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">HAP, hipertensi\u00f3n arterial pulmonar<\/span><\/span><span id=\"su_tooltip_69d0b1dc9f82b_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> en riesgo intermedio.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41ab60b4 elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"41ab60b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/\/es\/racional-y-diseno\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conozca acerca del dise\u00f1o del estudio REPLACE y del endpoint primario compuesto<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7c49e9c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c49e9c5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6966ae2b\" data-id=\"6966ae2b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b62fa1b elementor-widget elementor-widget-heading\" data-id=\"2b62fa1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">REPLACE: resultados clave<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64e7ae84 elementor-widget elementor-widget-text-editor\" data-id=\"64e7ae84\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>El estudio REPLACE alcanz\u00f3 su endpoint primario. El cambio de <span id=\"su_tooltip_69d0b1dca02e4_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dca02e4\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dca02e4\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69d0b1dca02e4_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> a riociguat result\u00f3 en una significativamente mayor proporci\u00f3n de pacientes con mejor\u00eda cl\u00ednica y significativamente menor tasa de deterioro cl\u00ednico comparado con permanecer en <span id=\"su_tooltip_69d0b1dca03aa_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69d0b1dca03aa\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69d0b1dca03aa\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69d0b1dca03aa_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d2d20d3 elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"6d2d20d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/\/es\/resultados-del-estudio\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conozca acerca de los resultados de REPLACE<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-41fe042a\" data-id=\"41fe042a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-89d48b8 animated-fast elementor-widget elementor-widget-image\" data-id=\"89d48b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;none&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"530\" height=\"392\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Home_Primary-endpoints_Spanish_v2-1.jpg\" class=\"attachment-full size-full wp-image-1079\" alt=\"\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Home_Primary-endpoints_Spanish_v2-1.jpg 530w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Home_Primary-endpoints_Spanish_v2-1-300x222.jpg 300w\" sizes=\"(max-width: 530px) 100vw, 530px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32cbcc30 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32cbcc30\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-35436c00\" data-id=\"35436c00\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5b96b9af elementor-section-stretched elementor-section-full_width elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"5b96b9af\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-181b192b\" data-id=\"181b192b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1e5d9a25 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1e5d9a25\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4458a25c\" data-id=\"4458a25c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5b83ff5 elementor-widget elementor-widget-image\" data-id=\"5b83ff5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"570\" height=\"547\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Professor-Marius-Hoeper.png\" class=\"attachment-large size-large wp-image-980\" alt=\"\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Professor-Marius-Hoeper.png 570w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Professor-Marius-Hoeper-300x288.png 300w\" sizes=\"(max-width: 570px) 100vw, 570px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6d813444\" data-id=\"6d813444\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-344eb8b3 elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"344eb8b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25dc4556 elementor-widget elementor-widget-heading\" data-id=\"25dc4556\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">El profesor Marius Hoeper<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e7a199d elementor-widget elementor-widget-heading\" data-id=\"3e7a199d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">presenta los resultados del estudio REPLACE<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2e8d42 elementor-widget elementor-widget-text-editor\" data-id=\"c2e8d42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En nombre de los investigadores de REPLACE, el profesor Marius Hoeper presenta un resumen de los hallazgos del estudio REPLACE<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37efd3d8 elementor-align-left elementor-mobile-align-center wplightbox elementor-widget elementor-widget-button\" data-id=\"37efd3d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/videos\/REPLACE-study-presentation_es.mp4\" id=\"mainvid\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Ver el video de resultados<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4abb1050 elementor-section-stretched elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"4abb1050\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3819e5b1\" data-id=\"3819e5b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-70a946f9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"70a946f9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-7edc9b65\" data-id=\"7edc9b65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4da1f846 elementor-widget elementor-widget-heading\" data-id=\"4da1f846\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Racional y dise\u00f1o del estudio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2be6f8d0 elementor-widget elementor-widget-image\" data-id=\"2be6f8d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"210\" height=\"140\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/studydesign.png\" class=\"attachment-large size-large wp-image-984\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74c42081 elementor-widget elementor-widget-text-editor\" data-id=\"74c42081\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Conozca acerca del racional y el dise\u00f1o del estudio REPLACE<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51a26697 elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"51a26697\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10df3409 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"10df3409\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/es\/racional-y-diseno\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Click aqu\u00ed<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-30a685ab\" data-id=\"30a685ab\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f122808 elementor-widget elementor-widget-heading\" data-id=\"7f122808\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Resultados del estudio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45ffb028 elementor-widget elementor-widget-image\" data-id=\"45ffb028\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"210\" height=\"140\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/studyresults.png\" class=\"attachment-large size-large wp-image-986\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4510a60a elementor-widget elementor-widget-text-editor\" data-id=\"4510a60a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Vea la presentaci\u00f3n de los resultados del estudio y datos de soporte<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-749bcfe elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"749bcfe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20f62608 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"20f62608\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/es\/resultados-del-estudio\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Click aqu\u00ed<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-24898732\" data-id=\"24898732\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7590c800 elementor-widget elementor-widget-heading\" data-id=\"7590c800\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bibliograf\u00eda<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2bae173b elementor-widget elementor-widget-image\" data-id=\"2bae173b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"210\" height=\"140\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/resources.png\" class=\"attachment-large size-large wp-image-988\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b792384 elementor-widget elementor-widget-text-editor\" data-id=\"3b792384\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Encuentre bibliograf\u00eda asociada con el estudio, incluyendo otras publicaciones de riociguat<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b9485fd elementor-align-center elementor-widget elementor-widget-button\" data-id=\"5b9485fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/es\/bibliografia\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Click 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El cambio a riociguat puede ser una opci\u00f3n de tratamiento para estos pacientes. El estudio REPLACE evalu\u00f3 la eficacia y seguridad del cambio de a riociguat &#8230; <a title=\"Inicio\" class=\"read-more\" href=\"https:\/\/www.replace-study.com\/es\/\" aria-label=\"Leer m\u00e1s sobre Inicio\">Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1067","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Inicio - The REPLACE study<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.replace-study.com\/es\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inicio - The REPLACE study\" \/>\n<meta property=\"og:description\" content=\"Bienvenido al estudio REPLACE Los datos cl\u00ednicos indican que entre el 20%-60% de los pacientes con que se encuentran recibiendo no logran alcanzar o mantener los objetivos de tratamiento. 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