{"id":1106,"date":"2021-02-09T12:30:28","date_gmt":"2021-02-09T12:30:28","guid":{"rendered":"http:\/\/localhost\/replace\/resultados-del-estudio\/"},"modified":"2025-08-12T12:56:08","modified_gmt":"2025-08-12T12:56:08","slug":"resultados-del-estudio","status":"publish","type":"page","link":"https:\/\/www.replace-study.com\/es\/resultados-del-estudio\/","title":{"rendered":"Resultados del estudio"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1106\" class=\"elementor elementor-1106\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-608e2aaa elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"608e2aaa\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2f301b9d\" data-id=\"2f301b9d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3de928cb elementor-widget__width-inherit elementor-widget elementor-widget-shortcode\" data-id=\"3de928cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n\t\t\t\t<p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t\t<sr7-module data-alias=\"study-results-ES\" data-id=\"17\" id=\"SR7_17_1\" class=\"rs-ov-hidden\" data-version=\"6.7.53\">\n\t\t\t\t\t<sr7-adjuster><\/sr7-adjuster>\n\t\t\t\t\t<sr7-content>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_17_1-9\" data-key=\"9\">\n\t\t\t\t\t\t\t<sr7-bg id=\"SR7_17_1-9-10\" class=\"sr7-layer\"><noscript><img decoding=\"async\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/globeheader.png\" alt=\"Globe Header\" title=\"Globe Header\"><\/noscript><\/sr7-bg>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_17_1-9-2\" class=\"sr7-layer\">Resultados de <strong>REPLACE<\/strong><\/sr7-txt>\n\t\t\t\t\t\t\t<p id=\"SR7_17_1-9-3\" class=\"sr7-layer\"><\/p>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_17_1-9-9\" class=\"sr7-layer\"><i class=\"fa-quote-left\"><\/i> &nbsp; El cambio de iPDE5 a riociguat tuvo una significativamente m\u00e1s alta probabilidad de mejor\u00eda cl\u00ednica y significativamente menor tasa de deterioro cl\u00ednico comparado con los pacientes que permanecieron en iPDE5 <i class=\"fa-quote-right\"><\/i><br \/>\n<br \/>\n<\/sr7-txt>\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_17_1-13\" data-key=\"13\">\n\t\t\t\t\t\t\t<sr7-bg id=\"SR7_17_1-13-16\" class=\"sr7-layer\"><noscript><img decoding=\"async\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/globeheader.png\" alt=\"Globe Header\" title=\"Globe Header\"><\/noscript><\/sr7-bg>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_17_1-13-2\" class=\"sr7-layer\">El estudio <strong>REPLACE<\/strong><\/sr7-txt>\n\t\t\t\t\t\t\t<p id=\"SR7_17_1-13-3\" class=\"sr7-layer\"><\/p>\n\t\t\t\t\t\t\t<a id=\"SR7_17_1-13-7\" class=\"sr7-layer\" href=\"https:\/\/www.thelancet.com\/journals\/lanres\/article\/PIIS2213-2600(20)30532-4\/fulltext\" target=\"_blank\" rel=\"nofollow noopener\">Haga click aqu\u00ed para ver la publicaci\u00f3n <i class=\"fa-chevron-right\"><\/i><\/a>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_17_1-13-9\" class=\"sr7-layer\">est\u00e1 ahora publicado en<\/sr7-txt>\n\t\t\t\t\t\t\t<sr7-txt id=\"SR7_17_1-13-15\" class=\"sr7-layer\">The Lancet Respiratory Medicine.<\/sr7-txt>\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t\t<sr7-slide id=\"SR7_17_1-22\" data-key=\"22\">\n\t\t\t\t\t\t<\/sr7-slide>\n\t\t\t\t\t<\/sr7-content>\n\t\t\t\t\t<image_lists style=\"display:none\">\n\t\t\t\t\t\t<img data-src=\"\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/rightangle.png\" data-libid=\"96\" data-lib=\"medialibrary\" alt=\"Right Angle\" title=\"Right Angle\" width=\"0\" height=\"0\" data-dbsrc=\"Ly93d3cucmVwbGFjZS1zdHVkeS5jb20vd3AtY29udGVudC91cGxvYWRzLzIwMjAvMDgvcmlnaHRhbmdsZS5wbmc=\"\/>\n\t\t\t\t\t\t<img data-src=\"\/\/www.replace-study.com\/wp-content\/uploads\/2020\/08\/globeheader.png\" data-libid=\"97\" data-lib=\"medialibrary\" alt=\"Globe Header\" title=\"Globe Header\" width=\"0\" height=\"0\" data-dbsrc=\"Ly93d3cucmVwbGFjZS1zdHVkeS5jb20vd3AtY29udGVudC91cGxvYWRzLzIwMjAvMDgvZ2xvYmVoZWFkZXIucG5n\"\/>\n\t\t\t\t\t\t<img data-src=\"\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/REPLACE-ms-screenshot.jpg\" data-libid=\"1288\" data-lib=\"medialibrary\" title=\"REPLACE ms screenshot\" width=\"0\" height=\"0\" data-dbsrc=\"Ly93d3cucmVwbGFjZS1zdHVkeS5jb20vd3AtY29udGVudC91cGxvYWRzLzIwMjEvMDMvUkVQTEFDRS1tcy1zY3JlZW5zaG90LmpwZw==\"\/>\n\t\t\t\t\t<\/image_lists>\n\t\t\t\t<\/sr7-module>\n\t\t\t\t<script>\n\t\t\t\t\twindow.SR7 ??={};SR7.PMH ??={}; SR7.PMH[\"SR7_17_1\"] = {cn:100,state:false,fn: function() { if (window._tpt!==undefined && window._tpt.prepareModuleHeight !== undefined) {  _tpt.prepareModuleHeight({id:\"SR7_17_1\",el:[400,400,400,300,180],type:'standard',shdw:'0',gh:[400,400,400,300,180],gw:[1240,1240,1024,778,480],vpt:['-200px&#039;,&#039;-200px&#039;,&#039;-200px&#039;,&#039;-200px&#039;,&#039;-200px'],size:{fullWidth:true, fullHeight:false},mh:'0',onh:0,onw:0,bg:{color:'{\"orig\":\"transparent\",\"type\":\"solid\",\"string\":\"transparent\"}'},plType:'0',plColor:'#FFFFFF'});   SR7.PMH[\"SR7_17_1\"].state=true;} else if(SR7.PMH[\"SR7_17_1\"].cn-->0)\tsetTimeout( SR7.PMH[\"SR7_17_1\"].fn,19);}};SR7.PMH[\"SR7_17_1\" ].fn();\n\t\t\t\t<\/script>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7d87675 elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7d87675\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3ccae3ac\" data-id=\"3ccae3ac\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3fd18387 elementor-widget elementor-widget-heading\" data-id=\"3fd18387\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Resultados del estudio REPLACE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-286648ae elementor-widget elementor-widget-text-editor\" data-id=\"286648ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>El estudio REPLACE alcanz\u00f3 su endpoint primario. El cambio de <span id=\"su_tooltip_69e132fe06fc3_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe06fc3\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe06fc3\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe06fc3_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> a riociguat result\u00f3 en una significativamente mayor proporci\u00f3n de pacientes con mejor\u00eda cl\u00ednica y significativamente menor tasa de deterioro cl\u00ednico comparado con permanecer en <span id=\"su_tooltip_69e132fe070ec_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe070ec\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe070ec\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe070ec_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4dc657f5\" data-id=\"4dc657f5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-69dc4735 elementor-widget elementor-widget-html\" data-id=\"69dc4735\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<svg width=\"230\" height=\"200\" viewBox=\"0 0 100 66.92\"><defs><style>.cls-1,.cls-7{fill:none;}.cls-2{fill:#b5def1;}.cls-3{fill:#90cdea;}.cls-4{fill:#6abde4;}.cls-5{fill:#46acdc;}.cls-6{clip-path:url(#clip-path);}.cls-7{stroke:#093549;stroke-linecap:round;stroke-miterlimit:10;stroke-width:4px;}<\/style><clipPath 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data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%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\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"281\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Thumbnail.png\" class=\"attachment-full size-full wp-image-1014\" alt=\"\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Thumbnail.png 500w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Thumbnail-300x169.png 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Reproducir v\u00eddeo\" tabindex=\"0\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-play\"><\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1bc1282a\" data-id=\"1bc1282a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5fb4005d elementor-widget elementor-widget-heading\" data-id=\"5fb4005d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Presentaci\u00f3n de los resultados del estudio REPLACE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1971c7a8 elementor-widget elementor-widget-text-editor\" data-id=\"1971c7a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En nombre de los investigadores de REPLACE, el profesor Marius Hoeper presenta los hallazgos de REPLACE.<\/p>\n<p>En este video resumen, el profesor Marius Hoeper presenta el racional y dise\u00f1o, resultados e implicancias cl\u00ednicas del estudio.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1028563f elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"1028563f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2c873a30\" data-id=\"2c873a30\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4f5bb101 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4f5bb101\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-1a85b3f8\" data-id=\"1a85b3f8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1441d3be elementor-widget elementor-widget-heading\" data-id=\"1441d3be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Resumen de los hallazgos clave<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4a43b87c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4a43b87c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-bda0543\" data-id=\"bda0543\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-29f58728 elementor-widget elementor-widget-text-editor\" data-id=\"29f58728\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Los pacientes que cambiaron de un <span id=\"su_tooltip_69e132fe084b1_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes toolwhite\" aria-describedby=\"su_tooltip_69e132fe084b1\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe084b1\" class=\"su-tooltip toolwhite\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe084b1_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> a riociguat tuvieron una significativamente mayor probabilidad de mejor\u00eda cl\u00ednica y significativamente menor tasa de deterioro cl\u00ednico comparado con los pacientes que se mantuvieron con <span id=\"su_tooltip_69e132fe0859f_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes toolwhite\" aria-describedby=\"su_tooltip_69e132fe0859f\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe0859f\" class=\"su-tooltip toolwhite\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe0859f_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6f09e9a4\" data-id=\"6f09e9a4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-26b55f0 elementor-widget elementor-widget-image\" data-id=\"26b55f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"144\" height=\"52\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/legend-ES-1.jpg\" class=\"attachment-medium size-medium wp-image-1280\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1fed34cc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1fed34cc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-2419f438\" data-id=\"2419f438\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-17bbaa29 elementor-widget elementor-widget-text-editor\" data-id=\"17bbaa29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"primary\"><h4 style=\"color: #003549; font-weight: 600;\">Endoint primario<\/h4><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1268 size-full\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/Results_Primary-endpoints_Spanish_Ali.jpg\" alt=\"Primary endpoints_Spanish\" width=\"528\" height=\"163\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/Results_Primary-endpoints_Spanish_Ali.jpg 528w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/Results_Primary-endpoints_Spanish_Ali-300x93.jpg 300w\" sizes=\"(max-width: 528px) 100vw, 528px\" \/><\/p><\/div><div class=\"secondary\"><h4 style=\"color: #003549; font-weight: 600;\">Endpoints secundarios<sup>a<\/sup><\/h4><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1276 size-full\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/secondary-endpoints-es-1.jpg\" alt=\"secondary-endpoints-es\" width=\"530\" height=\"387\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/secondary-endpoints-es-1.jpg 530w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/secondary-endpoints-es-1-300x219.jpg 300w\" sizes=\"(max-width: 530px) 100vw, 530px\" \/><\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1a43f7d\" data-id=\"1a43f7d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-765a1a67 elementor-widget elementor-widget-text-editor\" data-id=\"765a1a67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"secondary\"><h4 style=\"color: #003549; font-weight: 600;\">Seguridad<\/h4><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1273 size-full\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/Results_Safety_Spanish_Ali.jpg\" alt=\"Results_Safety_Spanish\" width=\"528\" height=\"163\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/Results_Safety_Spanish_Ali.jpg 528w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/03\/Results_Safety_Spanish_Ali-300x93.jpg 300w\" sizes=\"(max-width: 528px) 100vw, 528px\" \/><\/p><\/div><div class=\"secondarypad\"><h4 style=\"color: #003549; font-weight: 600;\">Perfil de riesgo a la Semana 24<\/h4><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-574 size-full\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/09\/riskprofiles-1.jpg\" alt=\"Seguridad\" width=\"530\" height=\"214\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/09\/riskprofiles-1.jpg 530w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/09\/riskprofiles-1-300x121.jpg 300w\" sizes=\"(max-width: 530px) 100vw, 530px\" \/><\/p><\/div><p>\u2022REPLACE es el primer estudio randomizado y controlado (<span id=\"su_tooltip_69e132fe099eb_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe099eb\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">ERC<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe099eb\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">ERC, estudio randomizado controlado<\/span><\/span><span id=\"su_tooltip_69e132fe099eb_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>) en pacientes con <span id=\"su_tooltip_69e132fe09ae6_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09ae6\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">HAP<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09ae6\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">HAP, hipertensi\u00f3n arterial pulmonar<\/span><\/span><span id=\"su_tooltip_69e132fe09ae6_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> evaluando el cambio de f\u00e1rmacos dentro de la misma v\u00eda, y tambi\u00e9n el primer <span id=\"su_tooltip_69e132fe09b98_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09b98\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">ERC<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09b98\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">ERC, estudio randomizado controlado<\/span><\/span><span id=\"su_tooltip_69e132fe09b98_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> cabeza a cabeza entre f\u00e1rmacos espec\u00edficos para la <span id=\"su_tooltip_69e132fe09c47_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09c47\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">HAP<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09c47\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">HAP, hipertensi\u00f3n arterial pulmonar<\/span><\/span><span id=\"su_tooltip_69e132fe09c47_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>.<\/p><p>\u2022 Riociguat fue generalmente bien tolerado en los pacientes que cambiaron desde un <span id=\"su_tooltip_69e132fe09ce5_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09ce5\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09ce5\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe09ce5_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>. Las tasas generales de <span id=\"su_tooltip_69e132fe09d80_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09d80\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">EA<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09d80\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">AE, adverse event<\/span><\/span><span id=\"su_tooltip_69e132fe09d80_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> fueron similares en ambos grupos, con una mayor incidencia de <span id=\"su_tooltip_69e132fe09e43_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09e43\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">EAS<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09e43\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">SAE, serious adverse event<\/span><\/span><span id=\"su_tooltip_69e132fe09e43_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> en el grupo <span id=\"su_tooltip_69e132fe09ef5_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09ef5\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09ef5\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe09ef5_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>.<\/p><p>\u2022 REPLACE demostr\u00f3 que el cambio de un <span id=\"su_tooltip_69e132fe09f99_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe09f99\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe09f99\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe09f99_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> (\u00b1 ERA) a riociguat puede beneficiar a pacientes con <span id=\"su_tooltip_69e132fe0a046_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe0a046\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">HAP<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe0a046\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">HAP, hipertensi\u00f3n arterial pulmonar<\/span><\/span><span id=\"su_tooltip_69e132fe0a046_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> en riesgo intermedio y puede ser considerada como una opci\u00f3n estrat\u00e9gica para progresar el tratamiento.<\/p><p>\u2022 Al optimizar la v\u00eda del <span id=\"su_tooltip_69e132fe0a0dd_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe0a0dd\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">ON<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe0a0dd\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">ON, \u00f3xido n\u00edtrico<\/span><\/span><span id=\"su_tooltip_69e132fe0a0dd_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>&#8211;<span id=\"su_tooltip_69e132fe0a168_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe0a168\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">GCs<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe0a168\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">GCs, guanilato ciclasa soluble<\/span><\/span><span id=\"su_tooltip_69e132fe0a168_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span>&#8211;<span id=\"su_tooltip_69e132fe0a20e_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe0a20e\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">GMPc<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe0a20e\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">GMPc, guanos\u00edn monofosfato c\u00edclico<\/span><\/span><span id=\"su_tooltip_69e132fe0a20e_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> cambiando un <span id=\"su_tooltip_69e132fe0a29d_button\" class=\"su-tooltip-button su-tooltip-button-outline-yes tool\" aria-describedby=\"su_tooltip_69e132fe0a29d\" data-settings='{\"position\":\"top\",\"behavior\":\"hover\",\"hideDelay\":0}' tabindex=\"0\">iPDE5<\/span><span style=\"display:none;z-index:100\" id=\"su_tooltip_69e132fe0a29d\" class=\"su-tooltip tool\" role=\"tooltip\"><span class=\"su-tooltip-inner su-tooltip-shadow-no\" style=\"z-index:100;background:#505050;color:#F3F3F3;font-size:14px;border-radius:0px;text-align:left;max-width:300px;line-height:1.25\"><span class=\"su-tooltip-title\"><\/span><span class=\"su-tooltip-content su-u-trim\">iPDE5, inhibidor de fosfodieterasa 5<\/span><\/span><span id=\"su_tooltip_69e132fe0a29d_arrow\" class=\"su-tooltip-arrow\" style=\"z-index:100;background:#505050\" data-popper-arrow><\/span><\/span> a riociguat los pacientes pueden permanecer en monoterapia o terapia combinada dual oral, retrasando la adici\u00f3n de otras terapias a una etapa posterior.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-de2ff6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"de2ff6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-657fa37e\" data-id=\"657fa37e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-77500e4e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"77500e4e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1e083699\" data-id=\"1e083699\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27f8cf44 elementor-widget elementor-widget-text-editor\" data-id=\"27f8cf44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"fontsmall\"><sup>a<\/sup>Los endpoints secundarios no ten\u00edan la potencia estad\u00edstica suficiente para demostrar efecto.<br \/>\n<sup>b<\/sup>El perfil de riesgo de ambos grupos era similar en la evaluaci\u00f3n basal.<br \/>\n<sup>c<\/sup>La evaluaci\u00f3n no invasiva Francesa se refiere al n\u00famero de par\u00e1metros en el rango de bajo riesgo.<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6bcd00aa\" data-id=\"6bcd00aa\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4e6d847b elementor-align-justify elementor-invisible elementor-widget elementor-widget-button\" data-id=\"4e6d847b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;pulse&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2020\/09\/Replace-Leaflet_v11.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-file-pdf\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Descargue el resumen del estudio REPLACE<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1dfa8a7 elementor-section-stretched elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"1dfa8a7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7bbce779\" data-id=\"7bbce779\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-74159dca elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"74159dca\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4929f295\" data-id=\"4929f295\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50673df2 elementor-widget elementor-widget-heading\" data-id=\"50673df2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Racional y dise\u00f1o del estudio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22c71a43 elementor-widget elementor-widget-image\" data-id=\"22c71a43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"210\" height=\"140\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/studydesign-1.png\" class=\"attachment-large size-large wp-image-1025\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d49ed4f elementor-widget elementor-widget-text-editor\" data-id=\"3d49ed4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Conozca acerca del racional y el dise\u00f1o del estudio REPLACE<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5136d43b elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"5136d43b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57251236 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"57251236\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/es\/racional-y-diseno\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conozca m\u00e1s<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-1c941ff1\" data-id=\"1c941ff1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2867dd68 elementor-widget elementor-widget-heading\" data-id=\"2867dd68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Resumen del estudio<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a82d24 elementor-widget__width-initial elementor-widget elementor-widget-video\" data-id=\"7a82d24\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;http:\\\/\\\/localhost\\\/replace\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/Thumbnail.png&quot;,&quot;id&quot;:1014,&quot;size&quot;:&quot;&quot;},&quot;lightbox&quot;:&quot;yes&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-lightbox\">\n\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox=\"{&quot;type&quot;:&quot;video&quot;,&quot;videoType&quot;:&quot;hosted&quot;,&quot;url&quot;:&quot;https:\\\/\\\/www.replace-study.com\\\/wp-content\\\/uploads\\\/videos\\\/REPLACE-study-summary.mp4&quot;,&quot;autoplay&quot;:&quot;&quot;,&quot;modalOptions&quot;:{&quot;id&quot;:&quot;elementor-lightbox-7a82d24&quot;,&quot;entranceAnimation&quot;:&quot;&quot;,&quot;entranceAnimation_tablet&quot;:&quot;&quot;,&quot;entranceAnimation_mobile&quot;:&quot;&quot;,&quot;videoAspectRatio&quot;:&quot;169&quot;},&quot;videoParams&quot;:{&quot;controls&quot;:&quot;&quot;,&quot;preload&quot;:&quot;metadata&quot;,&quot;controlsList&quot;:&quot;nodownload&quot;}}\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%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%3D%3D\">\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"281\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Thumbnail.png\" class=\"attachment-full size-full wp-image-1014\" alt=\"\" srcset=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Thumbnail.png 500w, https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/Thumbnail-300x169.png 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Reproducir v\u00eddeo\" tabindex=\"0\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-play\"><\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4712179c elementor-widget elementor-widget-text-editor\" data-id=\"4712179c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Vea la presentaci\u00f3n final con el resumen<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b924b9f elementor-hidden-phone elementor-widget elementor-widget-spacer\" data-id=\"1b924b9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d328808 elementor-align-center wplightbox elementor-widget elementor-widget-button\" data-id=\"4d328808\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/videos\/REPLACE-study-summary_es.mp4\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Reproducir el video<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-11176747\" data-id=\"11176747\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ee9f3df elementor-widget elementor-widget-heading\" data-id=\"6ee9f3df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bibliograf\u00eda<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f3dd55f elementor-widget elementor-widget-image\" data-id=\"2f3dd55f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"210\" height=\"140\" src=\"https:\/\/www.replace-study.com\/wp-content\/uploads\/2021\/02\/resources.png\" class=\"attachment-large size-large wp-image-988\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f0102d9 elementor-widget elementor-widget-text-editor\" data-id=\"1f0102d9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Encuentre bibliograf\u00eda asociada con el estudio, incluyendo otras publicaciones de riociguat<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6804c793 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6804c793\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.replace-study.com\/\/es\/bibliografia\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Conozca m\u00e1s<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-38c24911 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"38c24911\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4ea2ece5\" data-id=\"4ea2ece5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ea4fd38 elementor-widget elementor-widget-accordion\" data-id=\"6ea4fd38\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1851\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1851\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Bibliograf\u00eda<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1851\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1851\"><p>Hoeper MM et al Eur Respir J 2020 Vol 56 suppl 63, e-poster presented at the 2020 European Respiratory Society Virtual Congress<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-41d2abe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"41d2abe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-33ad0ad8\" data-id=\"33ad0ad8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6802da elementor-widget elementor-widget-html\" data-id=\"a6802da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.tool{\ntext-decoration:underline;\ntext-decoration-style: dotted;\ntext-decoration-color: #0791D2;\ntext-underline-position: under;\ncursor: pointer\n    }\n    .toolwhite{\ntext-decoration:underline;\ntext-decoration-style: dotted;\ntext-decoration-color: #ffffff;\ntext-underline-position: under;\ncursor: pointer\n    }\n    \n    .primary{\n    padding: 10px;\n    border-style: solid;\n    border-radius: 10px 10px 10px 10px;\n    border-width: 1px 1px 1px 1px;\n    border-color: #0F3549;\n    box-shadow: 2px 4px 10px 0px rgba(0,0,0,0.5);\n    transition: background 0.3s, border 0.3s, border-radius 0.3s, box-shadow 0.3s;\n    }\n        .secondary{\n    padding: 15px 10px 0px 10px;\n    }\n     .secondarypad{\n    padding: 0px 10px 0px 10px;\n    \n    }\n    .fontsmall{\n       font-size: 12px \n    }\n    .center{\n        align-content: center\n    }\n<\/style><script> \njQuery(document).ready(function($) { \nvar delay = 100; setTimeout(function() { \n$('.elementor-tab-title').removeClass('elementor-active');\n $('.elementor-tab-content').css('display', 'none'); }, delay); \n}); \n<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Resultados del estudio REPLACE El estudio REPLACE alcanz\u00f3 su endpoint primario. El cambio de a riociguat result\u00f3 en una significativamente mayor proporci\u00f3n de pacientes con mejor\u00eda cl\u00ednica y significativamente menor tasa de deterioro cl\u00ednico comparado con permanecer en . https:\/\/www.replace-study.com\/wp-content\/uploads\/videos\/REPLACE-study-presentation_es.mp4 Presentaci\u00f3n de los resultados del estudio REPLACE En nombre de los investigadores de REPLACE, el &#8230; <a title=\"Resultados del estudio\" class=\"read-more\" href=\"https:\/\/www.replace-study.com\/es\/resultados-del-estudio\/\" aria-label=\"Leer m\u00e1s sobre Resultados del estudio\">Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1106","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Resultados del estudio - The REPLACE study<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.replace-study.com\/es\/study-results\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resultados del estudio - The REPLACE study\" \/>\n<meta property=\"og:description\" content=\"Resultados del estudio REPLACE El estudio REPLACE alcanz\u00f3 su endpoint primario. 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